Diet Pills – Does Phentermine Work for Weight Loss?

Dosage and Types

In contrast to 3 other commonly prescribed drugs for weight loss, the combination of phentermine and topiramate was associated with the greatest likelihood of losing at least 5 percent of the initial body fat (14Trusted Source).

What Is Phentermine?

Taking phentermine helps curb your appetite, thus limiting the number of calories you consume. Over time, this can lead to weight reduction.


Phentermine is a member of a category of medications called”anorectics,” also called appetite suppressants.

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The Main Point

After choosing the lowest dose for 14 days, your physician can opt to progress you to a higher dose.

Though the specific mechanisms behind the appetite-reducing effects of phentermine remain unclear, the drug is supposed to act by increasing neurotransmitter levels in your brain (6Trusted Supply, 7Trusted Source).

Topiramate is a medication that has been used on its own to take care of seizures but — like phentermine — additionally has appetite-reducing properties (11Trusted Source, 12Trusted Source, 13Trusted Source).

Dosages for phentermine vary depending on its form and concentration.

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The combination of phentermine and topiramate appears to be even more effective and more tolerable compared to phentermine alone.

The anticipated average weight loss with phentermine use is 5% of your initial body weight. Yet, over 12 weeks, it is often as high as 10 percent.

What is more, research suggests that the phentermine and topiramate blend is the most effective weight loss medication so far — with individuals achieving an average weight loss of 21.6 pounds (9.8 kg) after taking the dose for a single year (15Trusted Source).


Within 28 days, treatment with all the phentermine and topiramate combination decreased the participants’ amount of binge-eating times from 16.2 to 4.2. The same results weren’t observed in the placebo group (20Trusted Source).

Your doctor can prescribe phentermine if you’re obese, meaning that your body mass index (BMI) is higher than or equal to 30.

Several clinical studies have shown that phentermine can boost fat loss.

In a tiny 12-week research in obese or obese people with BED, the phentermine and topiramate medication combination was associated with substantial reductions in fat, BMI, and binge-eating episode frequency (19Trusted Source).

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